MolNFT v1 · #173936 · protein
Structure of the integrator cleavage module with INTS4/9/11
7BFP · Integrator complex subunit 9: “Structure of the integrator cleavage module with INTS4/9/11”. Electron microscopy, 15 pockets (best druggability 0.87). MolNFT v1 #173936 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7BFP
- Type
- protein
- Length
- 1,358 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrator complex subunit 9; Integrator complex subunit 4; Integrator complex subunit…
- EC
- 3.1.27.-
- UniProt
- Q9NV88, Q96HW7, Q5TA45
- Pockets
- 15 · best druggability 0.87
Structure
electron microscopy · 4 distinct chains · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrator complex subunit 9 | protein | 526 | 27% helix, 22% strand | Q9NV88 |
| C | Integrator complex subunit 4 | protein | 298 | 68% helix, 1% strand | Q96HW7 |
| B | Integrator complex subunit 11 (EC 3.1.27.-) | protein | 498 | 32% helix, 18% strand | Q5TA45 |
| U | Unknown | protein | 36 | 67% helix, 0% strand | — |
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.87 | 0.89 | 129 | empty |
| 2 | 620 | 0.82 | 0.87 | 92 | empty |
| 3 | 327 | 0.75 | 0.87 | 55 | empty |
| 4 | 228 | 0.72 | 0.88 | 52 | empty |
| 5 | 141 | 0.64 | 0.86 | 33 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1729 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 1219 Ų buried · 12 hydrogen bonds · protein-protein
- C–B · 648 Ų buried · 1 hydrogen bond · protein-protein
- C–U · 325 Ų buried · 3 hydrogen bonds · protein-protein
- B–U · 49 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7BFP · Structure of the Integrator cleavage module with INTS4/9/11 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NV88 · AlphaFold monomer V2.0 prediction for integrator complex subunit 9 (Q9NV88) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q96HW7 · AlphaFold monomer V2.0 prediction for integrator complex subunit 4 (Q96HW7) · a predicted model of the same protein · chain C against A, TM-score 0.94
- Q5TA45 · AlphaFold monomer V2.0 prediction for integrator complex subunit 11 (Q5TA45) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NV88
- Every structure of UniProt Q96HW7
- Every structure of UniProt Q5TA45
- Elsewhere: RCSB PDB 7BFP · PDBe 7BFP · UniProt Q9NV88 · UniProt Q96HW7 · UniProt Q5TA45
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.