MolNFT v1 · #173871 · protein
Human BRR2 helicase region in complex with C-tail deleted JAB1 and atpgammas
7BDI · U5 small nuclear ribonucleoprotein 200 kda helicase: “Human BRR2 helicase region in complex with C-tail deleted JAB1 and atpgammas”. X-ray diffraction, 2 ligands (AGS, MG), 20 pockets (best druggability 0.82). MolNFT v1 #173871 on…
- PDB
- 7BDI
- Type
- protein
- Length
- 1,987 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U5 small nuclear ribonucleoprotein 200 kda helicase; Pre-mRNA-processing-splicing factor 8
- EC
- 3.6.4.13
- UniProt
- O75643, Q6P2Q9
- Ligands
- AGS, MG
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | U5 small nuclear ribonucleoprotein 200 kda helicase (EC 3.6.4.13) | protein | 1725 | 40% helix, 17% strand | O75643 |
| J | Pre-mRNA-processing-splicing factor 8 | protein | 262 | 24% helix, 25% strand | Q6P2Q9 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · 2 copies · chains B
- MG · Magnesium ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 890 | 0.82 | 0.84 | 82 | empty |
| 2 | 903 | 0.80 | 0.83 | 78 | empty |
| 3 | 753 | 0.76 | 0.81 | 78 | empty |
| 4 | 343 | 0.75 | 0.86 | 44 | empty |
| 5 | 730 | 0.74 | 0.79 | 47 | AGS, MG |
Interfaces
1 interface between chains.
- B–J · 1778 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7BDI · Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75643
- Every structure of UniProt Q6P2Q9
- Elsewhere: RCSB PDB 7BDI · PDBe 7BDI · UniProt O75643 · UniProt Q6P2Q9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.