MolNFT v1 · #173488 · protein

TRPC4 in complex with calmodulin

7B1G · Transient receptor potential cation channel subfamily C…: “TRPC4 in complex with calmodulin”. Electron microscopy, 2 ligands (44E, CA), 20 pockets (best druggability 0.85). MolNFT v1 #173488 on GenesisL1: 3D structure, binding sites…

PDB: 7B1G
Type: protein
Length: 2,689 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily C member 4A; Calmodulin-1
UniProt: U3N7D8, P0DP26
Ligands: 44E, CA
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 3 distinct chains · 62% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transient receptor potential cation channel subfamily C member 4A	protein	691	64% helix, 0% strand	U3N7D8
E	Calmodulin-1	protein	48	23% helix, 0% strand	P0DP26
B, C, D	Transient receptor potential cation channel subfamily C member 4A	protein	650	62% helix, 1% strand	U3N7D8

Ligands and binding sites

44E · (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate · ligand · 4 copies · chains A, C, B, D
CA · Calcium ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1044	0.85	0.86	69	empty
2	951	0.80	0.82	74	empty
3	826	0.80	0.83	62	empty
4	873	0.79	0.81	61	CA
5	909	0.79	0.81	67	CA

Interfaces

7 interfaces between chains.

A–B · 4555 Å² buried · 22 hydrogen bonds · protein-protein
A–C · 4500 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 4499 Å² buried · 18 hydrogen bonds · protein-protein
B–D · 4460 Å² buried · 20 hydrogen bonds · protein-protein
A–E · 519 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7B1G · TRPC4 in complex with Calmodulin · the same entry in another collection · chain A against A, TM-score 1.00
P0DP26 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP26) · a predicted model of the same protein · chain E against A, TM-score 0.60

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt U3N7D8
Every structure of UniProt P0DP26
Elsewhere: RCSB PDB 7B1G · PDBe 7B1G · UniProt U3N7D8 · UniProt P0DP26

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