MolNFT v1 · #173132 · protein
Yeast tho-SUB2 complex
7APX · Tho complex subunit 2,THO2: “Yeast tho-SUB2 complex”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #173132 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7APX
- Type
- protein
- Length
- 2,889 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tho complex subunit 2,THO2; Tho complex subunit HPR1; Tho complex subunit THP2; Tho…
- EC
- 3.6.4.13
- UniProt
- P53552, P17629, O13539, P33441, P53851, Q07478
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 6 distinct chains · 55% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tho complex subunit 2,THO2 | protein | 1165 | 65% helix, 3% strand | P53552 |
| B | Tho complex subunit HPR1 | protein | 563 | 57% helix, 0% strand | P17629 |
| C | Tho complex subunit THP2 | protein | 227 | 76% helix, 1% strand | O13539 |
| D | Tho complex subunit MFT1 | protein | 225 | 76% helix, 0% strand | P33441 |
| E | Protein TEX1 | protein | 348 | 7% helix, 39% strand | P53851 |
| F | ATP-dependent RNA helicase SUB2 (EC 3.6.4.13) | protein | 361 | 42% helix, 17% strand | Q07478 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1104 | 0.85 | 0.86 | 105 | empty |
| 2 | 1123 | 0.85 | 0.86 | 114 | empty |
| 3 | 707 | 0.81 | 0.84 | 111 | empty |
| 4 | 383 | 0.81 | 0.89 | 62 | empty |
| 5 | 802 | 0.80 | 0.83 | 71 | empty |
Interfaces
10 interfaces between chains.
- A–B · 6639 Ų buried · 41 hydrogen bonds · protein-protein
- C–D · 3764 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2464 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 2044 Ų buried · 9 hydrogen bonds · protein-protein
- A–E · 1677 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7APX · yeast THO-Sub2 complex · the same entry in another collection · chain F against F, TM-score 1.00
- P53851 · AlphaFold monomer V2.0 prediction for protein TEX1 (P53851) · a predicted model of the same protein · chain E against A, TM-score 0.99
- P53552 · AlphaFold monomer V2.0 prediction for tho complex subunit 2 (P53552) · a predicted model of the same protein · chain A against A, TM-score 0.86
- Q07478 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase SUB2 (Q07478) · a predicted model of the same protein · chain F against A, TM-score 0.68
- P33441 · AlphaFold monomer V2.0 prediction for tho complex subunit MFT1 (P33441) · a predicted model of the same protein · chain D against A, TM-score 0.44
- P17629 · AlphaFold monomer V2.0 prediction for tho complex subunit HPR1 (P17629) · a predicted model of the same protein · chain B against A, TM-score 0.44
- O13539 · AlphaFold monomer V2.0 prediction for tho complex subunit THP2 (O13539) · a predicted model of the same protein · chain C against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53552
- Every structure of UniProt P17629
- Every structure of UniProt O13539
- Every structure of UniProt P33441
- Every structure of UniProt P53851
- Every structure of UniProt Q07478
- Elsewhere: RCSB PDB 7APX · PDBe 7APX · UniProt P53552 · UniProt P17629 · UniProt O13539 · UniProt P33441 · UniProt P53851 · UniProt Q07478
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