MolNFT v1 · #173005 · protein
Human gch-gfrp stimulatory complex
7ALC · GTP cyclohydrolase 1: “Human gch-gfrp stimulatory complex”. X-ray diffraction, 2 ligands (PHE, ZN), 16 pockets (best druggability 0.89). MolNFT v1 #173005 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ALC
- Type
- protein
- Length
- 1,282 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase 1; GTP cyclohydrolase 1 feedback regulatory protein
- EC
- 3.5.4.16
- UniProt
- P30793, P30047
- Ligands
- PHE, ZN
- Pockets
- 16 · best druggability 0.89
Structure
x-ray diffraction · 9 distinct chains · 39% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 184 | 47% helix, 28% strand | P30793 |
| B | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 166 | 48% helix, 27% strand | P30793 |
| C | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 162 | 43% helix, 28% strand | P30793 |
| D | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 182 | 47% helix, 28% strand | P30793 |
| E | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 171 | 50% helix, 26% strand | P30793 |
| F, H | GTP cyclohydrolase 1 feedback regulatory protein | protein | 83 | 19% helix, 41% strand | P30047 |
| G | GTP cyclohydrolase 1 feedback regulatory protein | protein | 84 | 19% helix, 43% strand | P30047 |
| I | GTP cyclohydrolase 1 feedback regulatory protein | protein | 85 | 20% helix, 40% strand | P30047 |
| J | GTP cyclohydrolase 1 feedback regulatory protein | protein | 82 | 18% helix, 38% strand | P30047 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · 5 copies · chains B, F, G, A, J, C, H, D, I, E
- ZN · Zinc ion · metal · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1185 | 0.89 | 0.91 | 148 | PHE |
| 2 | 286 | 0.74 | 0.87 | 51 | PHE |
| 3 | 202 | 0.74 | 0.90 | 43 | PHE |
| 4 | 138 | 0.65 | 0.87 | 32 | empty |
| 5 | 207 | 0.58 | 0.80 | 37 | empty |
Interfaces
23 interfaces between chains.
- G–H · 1098 Ų buried · 15 hydrogen bonds · protein-protein
- I–J · 1089 Ų buried · 13 hydrogen bonds · protein-protein
- F–J · 1072 Ų buried · 12 hydrogen bonds · protein-protein
- H–I · 1047 Ų buried · 13 hydrogen bonds · protein-protein
- F–G · 1026 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7ALC · human GCH-GFRP stimulatory complex · the same entry in another collection · chain J against J, TM-score 1.00
- P30793 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 (P30793) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P30047 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 feedback regulatory protein… · a predicted model of the same protein · chain F against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30793
- Every structure of UniProt P30047
- Elsewhere: RCSB PDB 7ALC · PDBe 7ALC · UniProt P30793 · UniProt P30047
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