UniProt P30793
GTP cyclohydrolase 1 (P30793)
GTP cyclohydrolase 1 (UniProt P30793), EC 3.5.4.16: 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 145 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30793
- Protein
- GTP cyclohydrolase 1
- EC
- 3.5.4.16
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 145 · 8 records with a druggable one
Structures
21 records of P30793 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FB1 | Crystal structure of human GTP cyclohydrolase I | x-ray diffraction | A, B, C, D, E | — | — |
| 1FB1 | Crystal structure of human GTP cyclohydrolase I | x-ray diffraction | A, B, C, D, E | — | — |
| 6Z80 | stimulatory human GTP cyclohydrolase I - GFRP complex | electron microscopy | A, B, C, E, G, H, I, J, F, D | ZN, PHE, 8GT | 20 (best 0.83) |
| 6Z80 | Stimulatory human GTP cyclohydrolase I - gfrp complex | electron microscopy | A, B, C, E, G, H, I, J, F, D | ZN, 8GT | — |
| 6Z85 | Inhibitory human GTP cyclohydrolase I - gfrp complex | electron microscopy | A, C, D, B, E, G, H, I, J, F | ZN, HBI | — |
| 6Z86 | human GTP cyclohydrolase I in complex with 7-deaza-GTP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ | 20 (best 0.79) |
| 6Z86 | Human GTP cyclohydrolase I in complex with 7-deaza-GTP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ | — |
| 6Z87 | human GTP cyclohydrolase I | x-ray diffraction | A, B, C, D, E | ZN | 20 (best 0.79) |
| 6Z87 | Human GTP cyclohydrolase I | x-ray diffraction | A, B, C, D, E | ZN | — |
| 6Z88 | human GTP cyclohydrolase I in complex with allosteric inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | QBK, ZN | 20 (best 0.77) |
| 6Z88 | Human GTP cyclohydrolase I in complex with allosteric inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | QBK, ZN | — |
| 6Z89 | human GTP cyclohydrolase I in complex with allosteric inhibitor | x-ray diffraction | A, B, C, D, E | QBK, ZN | 10 (best 0.77) |
| 6Z89 | Human GTP cyclohydrolase I in complex with allosteric inhibitor | x-ray diffraction | A, B, C, D, E | QBK, ZN | — |
| 7ALA | human GCH-GFRP inhibitory complex | x-ray diffraction | A, B, C, D, E | ZN, 5RW | 15 (best 0.87) |
| 7ALA | Human gch-gfrp inhibitory complex | — | — | — | |
| 7ALB | human GCH-GFRP stimulatory complex 7-deaza-GTP bound | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ, PHE | 20 (best 0.89) |
| 7ALB | Human gch-gfrp stimulatory complex 7-deaza-GTP bound | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ | — |
| 7ALC | Human gch-gfrp stimulatory complex | x-ray diffraction | A, B, C, D, E | ZN | — |
| 7ALQ | human GCH-GFRP inhibitory complex 7-deaza-GTP bound | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ, HBI | 20 (best 0.87) |
| 7ALQ | Human gch-gfrp inhibitory complex 7-deaza-GTP bound | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | ZN, QBQ, HBI | — |
| P30793 | AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 (P30793) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 17 records
- QBQ · 7-deaza-GTP · in 6 records
- QBK · 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione · in 4 records
- HBI · 7,8-dihydrobiopterin · in 3 records
- 8GT · 8-oxo-guanosine-5'-triphosphate · in 2 records
- PHE · Phenylalanine · in 2 records
- 5RW · 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one · in 1 record
Experiment against prediction
- 6Z86 chain Q against the predicted model P30793: TM-score 1.00, RMSD 0.23 Å
- 6Z86 chain Q against the predicted model P30793: TM-score 1.00, RMSD 0.23 Å
- 6Z86 chain L against the predicted model P30793: TM-score 1.00, RMSD 0.23 Å
- 6Z86 chain L against the predicted model P30793: TM-score 1.00, RMSD 0.23 Å
- 6Z86 chain I against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
- 6Z86 chain I against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
- 6Z86 chain A against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
- 6Z86 chain A against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
- 6Z86 chain B against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
- 6Z86 chain B against the predicted model P30793: TM-score 1.00, RMSD 0.24 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.