Crystal structure of the prototype foamy virus (pfv) intasome in complex with magnesium and the insti XZ440 (compound 5J)

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• R7K · ~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-5-(hydroxymethyl)-1,4-bis(oxidanyl)-2-oxidanylidene-1,8-naphthyridine-3-carboxamide · ligand · chains A, C, D
• MG · Magnesium ion · metal · 2 copies · chains A
• ZN · Zinc ion · metal · chains A
• SO4 · Sulfate ion · ion · 11 copies · chains A, C, B, D
• GOL · Glycerol · additive · 6 copies · chains A, C, B, D
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7ADU · Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P14350
• Elsewhere: RCSB PDB 7ADU · PDBe 7ADU · UniProt P14350