MolNFT v1 · #172748 · protein

Human GTP cyclohydrolase I feedback regulatory protein (gfrp)

7ACC · GTP cyclohydrolase 1 feedback regulatory protein: “Human GTP cyclohydrolase I feedback regulatory protein (gfrp)”. X-ray diffraction, 1 ligand (K), 11 pockets (best druggability 0.85). MolNFT v1 #172748 on GenesisL1: 3D structure…

PDB: 7ACC
Type: protein
Length: 841 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTP cyclohydrolase 1 feedback regulatory protein
UniProt: P30047
Ligands: K
Pockets: 11 · best druggability 0.85

Structure

x-ray diffraction · 3 distinct chains · 19% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, F, I, J	GTP cyclohydrolase 1 feedback regulatory protein	protein	83	19% helix, 45% strand	P30047
C, E, G	GTP cyclohydrolase 1 feedback regulatory protein	protein	86	19% helix, 43% strand	P30047
H	GTP cyclohydrolase 1 feedback regulatory protein	protein	85	19% helix, 44% strand	P30047

Ligands and binding sites

K · Potassium ion · metal · 10 copies · chains A, B, C, D, E, F, G, H, I, J

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	341	0.85	0.96	40	empty
2	218	0.78	0.92	48	empty
3	128	0.70	0.91	34	empty
4	101	0.69	0.92	25	empty
5	92	0.67	0.92	24	empty

Interfaces

29 interfaces between chains.

H–I · 1090 Å² buried · 16 hydrogen bonds · protein-protein
G–H · 1086 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 1085 Å² buried · 16 hydrogen bonds · protein-protein
F–J · 1083 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 1072 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

7ACC · human GTP cyclohydrolase I feedback regulatory protein (GFRP) · the same entry in another collection · chain J against J, TM-score 1.00
P30047 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 feedback regulatory protein… · a predicted model of the same protein · chain J against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30047
Elsewhere: RCSB PDB 7ACC · PDBe 7ACC · UniProt P30047

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