Research workbench
Human GTP cyclohydrolase I feedback regulatory protein (gfrp)
Analyse Human GTP cyclohydrolase I feedback regulatory protein (gfrp) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ACC
- Type
- protein
- Length
- 841 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase 1 feedback regulatory protein
- UniProt
- P30047
- Ligands
- K
- Pockets
- 11 · best druggability 0.85
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, F, I, J | GTP cyclohydrolase 1 feedback regulatory protein | protein | 83 | 19% helix, 45% strand | P30047 |
| C, E, G | GTP cyclohydrolase 1 feedback regulatory protein | protein | 86 | 19% helix, 43% strand | P30047 |
| H | GTP cyclohydrolase 1 feedback regulatory protein | protein | 85 | 19% helix, 44% strand | P30047 |
Ligands and binding sites
- K · Potassium ion · metal · 10 copies · chains A, B, C, D, E, F, G, H, I, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.85 | 0.96 | 40 | empty |
| 2 | 218 | 0.78 | 0.92 | 48 | empty |
| 3 | 128 | 0.70 | 0.91 | 34 | empty |
| 4 | 101 | 0.69 | 0.92 | 25 | empty |
| 5 | 92 | 0.67 | 0.92 | 24 | empty |
Interfaces
29 interfaces between chains.
- H–I · 1090 Ų buried · 16 hydrogen bonds · protein-protein
- G–H · 1086 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1085 Ų buried · 16 hydrogen bonds · protein-protein
- F–J · 1083 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1072 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7ACC · human GTP cyclohydrolase I feedback regulatory protein (GFRP) · the same entry in another collection · chain J against J, TM-score 1.00
- P30047 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 feedback regulatory protein… · a predicted model of the same protein · chain J against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30047
- Elsewhere: RCSB PDB 7ACC · PDBe 7ACC · UniProt P30047
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