MolNFT v1 · #172545 · protein
Cryoem structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-BETA3 homopentamer, in complex with histamine and megabody MB25 in lipid nanodisc
7A5V: “Cryoem structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-BETA3 homopentamer, in complex…”. Electron microscopy, 7 ligands (D10, R16, HSM). MolNFT v1 #172545 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7A5V
- Type
- protein
- Length
- 455 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P28472
- Ligands
- D10, R16, HSM, NAG, MAN, BMA, CL
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 334 | — | P28472 |
| O | — | protein | 121 | — | — |
Ligands and binding sites
- D10 · Decane · ligand · 4 copies · chains A
- R16 · Hexadecane · ligand · chains A
- HSM · Histamine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, O
- MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A, O
- BMA · beta-D-mannopyranose · sugar · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- OCT · N-octane · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7A5V · CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3… · the same entry in another collection · chain A against A, TM-score 1.00
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28472
- Elsewhere: RCSB PDB 7A5V · PDBe 7A5V · UniProt P28472
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