Ompd-domain of human umps in complex with 6-carboxamido-ump at 1.2 ångströms resolution

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Ligands and binding sites

• QRT · [(2~{R},3~{S},4~{R},5~{R})-5-[6-aminocarbonyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl) oxolan-2-yl]methyl dihydrogen phosphate · ligand · chains A
• PRO · Proline · ligand · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6ZX2 · OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution · the same entry in another collection · chain A against A, TM-score 1.00
• P11172 · AlphaFold monomer V2.0 prediction for uridine 5'-monophosphate synthase (P11172) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11172
• Elsewhere: RCSB PDB 6ZX2 · PDBe 6ZX2 · UniProt P11172