MolNFT v1 · #172208 · protein

Human tfiis N-terminal domain in complex with IWS1

6ZV4 · Transcription elongation factor a protein 1,PROTEIN IWS1…: “Human tfiis N-terminal domain in complex with IWS1”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #172208 on GenesisL1: 3D structure, binding sites and…

PDB: 6ZV4
Type: protein
Length: 116 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription elongation factor a protein 1,PROTEIN IWS1 homolog
UniProt: P23193, Q96ST2
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 1 distinct chain · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription elongation factor a protein 1,PROTEIN IWS1 homolog	protein	116	62% helix, 0% strand	P23193, Q96ST2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.29	0.74	12	empty

Compared structures

6ZV4 · Human TFIIS N-terminal domain in complex with IWS1 · the same entry in another collection · chain A against A, TM-score 1.00
P23193 · AlphaFold monomer V2.0 prediction for transcription elongation factor a protein 1 (P23193) · a predicted model of the same protein · chain A against A, TM-score 0.69
Q96ST2 · AlphaFold monomer V2.0 prediction for protein IWS1 homolog (Q96ST2) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23193
Every structure of UniProt Q96ST2
Elsewhere: RCSB PDB 6ZV4 · PDBe 6ZV4 · UniProt P23193 · UniProt Q96ST2

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