UniProt Q96ST2
Protein IWS1 homolog (Q96ST2)
Protein IWS1 homolog (UniProt Q96ST2): 10 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96ST2
- Protein
- Protein IWS1 homolog
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 7 · 4 records with a druggable one
Structures
11 records of Q96ST2 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EMR | Solution structure of the LEDGF/P75 ibd - IWS1 (aa 446-548) complex | solution nmr | A | — | — |
| 6ZV1 | TFIIS N-terminal domain (TND) from human IWS1 | solution nmr | A | — | 1 (best 0.27) |
| 6ZV1 | Tfiis N-terminal domain (tnd) from human IWS1 | solution nmr | A | — | — |
| 6ZV4 | Human TFIIS N-terminal domain in complex with IWS1 | solution nmr | A | — | 1 (best 0.29) |
| 6ZV4 | Human tfiis N-terminal domain in complex with IWS1 | solution nmr | A | — | — |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | O | — | 1 (best 0.76) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | O | — | 2 (best 0.76) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | O | — | 1 (best 0.76) |
| 9EH1 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 20 bp upstream | electron microscopy | O | — | 1 (best 0.76) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | O | — | — |
| Q96ST2 | AlphaFold monomer V2.0 prediction for protein IWS1 homolog (Q96ST2) | predicted | A | — | — |
Experiment against prediction
- 9EH2 chain O against the predicted model Q96ST2: TM-score 0.95, RMSD 0.99 Å
- 9EH1 chain O against the predicted model Q96ST2: TM-score 0.95, RMSD 1.03 Å
- 9EGX chain O against the predicted model Q96ST2: TM-score 0.95, RMSD 1.04 Å
- 9EGZ chain O against the predicted model Q96ST2: TM-score 0.95, RMSD 1.04 Å
- 9EGY chain O against the predicted model Q96ST2: TM-score 0.95, RMSD 1.04 Å
- 6ZV1 chain A against the predicted model Q96ST2: TM-score 0.89, RMSD 2.10 Å
- 6ZV1 chain A against the predicted model Q96ST2: TM-score 0.89, RMSD 2.10 Å
- 6ZV4 chain A against the predicted model Q96ST2: TM-score 0.63, RMSD 2.61 Å
- 6ZV4 chain A against the predicted model Q96ST2: TM-score 0.63, RMSD 2.61 Å
- 6EMR chain A against the predicted model O75475: TM-score 0.41, RMSD 2.73 Å
Elsewhere
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