UniProt P23193
Transcription elongation factor A protein 1 (P23193)
Transcription elongation factor A protein 1 (UniProt P23193): 34 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 39 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P23193
- Protein
- Transcription elongation factor A protein 1
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 39 · 19 records with a druggable one
Structures
35 records of P23193 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TFI | A novel zn finger motif in the basal transcriptional machinery: three-dimensional NMR studies of… | solution nmr | A | ZN | — |
| 1TFI | A novel zn finger motif in the basal transcriptional machinery: three- dimensional NMR studies of… | solution nmr | A | ZN | — |
| 3NDQ | Structure of Human TFIIS Domain II | x-ray diffraction | A | NA | — |
| 3NDQ | Structure of human tfiis domain II | x-ray diffraction | A | NA | — |
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | U | ZN | 4 (best 0.88) |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | U | — | — |
| 5IY7 | Human holo-PIC in the open state | electron microscopy | U | MG, ZN | 4 (best 0.84) |
| 5IY7 | Human holo-pic in the open state | electron microscopy | U | — | — |
| 5IY8 | Human holo-PIC in the initial transcribing state | electron microscopy | U | MG, ZN | 4 (best 0.78) |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | U | — | — |
| 5IYA | Human core-PIC in the closed state | electron microscopy | U | ZN | 4 (best 0.87) |
| 5IYA | Human core-pic in the closed state | electron microscopy | U | — | — |
| 5IYB | Human core-PIC in the open state | electron microscopy | U | MG, ZN | 3 (best 0.86) |
| 5IYB | Human core-pic in the open state | electron microscopy | U | — | — |
| 5IYC | Human core-PIC in the initial transcribing state | electron microscopy | U | MG, ZN | 2 (best 0.87) |
| 5IYC | Human core-pic in the initial transcribing state | electron microscopy | U | — | — |
| 6O9L | Human holo-PIC in the closed state | electron microscopy | U | MG, ZN | 1 (best 0.81) |
| 6O9L | Human holo-pic in the closed state | electron microscopy | U | MG, ZN | — |
| 6ZUY | Human TFIIS N-terminal domain (TND) | solution nmr | A | — | — |
| 6ZUY | Human tfiis N-terminal domain (tnd) | solution nmr | A | — | — |
| 6ZV4 | Human TFIIS N-terminal domain in complex with IWS1 | solution nmr | A | — | 1 (best 0.29) |
| 6ZV4 | Human tfiis N-terminal domain in complex with IWS1 | solution nmr | A | — | — |
| 7CNF | Solution strcture of HsTFIIS LW domain | solution nmr | A | — | 2 (best 0.56) |
| 7CNF | Solution strcture of hstfiis lw domain | solution nmr | A | — | — |
| 7UNC | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | electron microscopy | O | — | 1 (best 0.76) |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | O | — | 1 (best 0.78) |
| 8A40 | Structure of mammalian Pol II-TFIIS elongation complex | electron microscopy | U | ZN | 4 (best 0.75) |
| 8UIS | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | electron microscopy | S | — | 1 (best 0.76) |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | S | — | 1 (best 0.78) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | S | — | 1 (best 0.78) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | S | — | 1 (best 0.78) |
| 9EH0 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream | electron microscopy | S | — | 1 (best 0.78) |
| 9EH1 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 20 bp upstream | electron microscopy | S | — | 1 (best 0.78) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | S | — | 1 (best 0.78) |
| P23193 | AlphaFold monomer V2.0 prediction for transcription elongation factor a protein 1 (P23193) | predicted | A | — | 1 (best 0.72) |
Ligands
Experiment against prediction
- 7UNC chain O against the predicted model P23193: TM-score 1.00, RMSD 0.00 Å
- 7UND chain O against the predicted model P23193: TM-score 1.00, RMSD 0.00 Å
- 9EGX chain S against the predicted model P23193: TM-score 0.99, RMSD 0.49 Å
- 9EGY chain S against the predicted model P23193: TM-score 0.99, RMSD 0.49 Å
- 9EGZ chain S against the predicted model P23193: TM-score 0.99, RMSD 0.51 Å
- 9EH0 chain S against the predicted model P23193: TM-score 0.99, RMSD 0.54 Å
- 3NDQ chain A against the predicted model P23193: TM-score 0.99, RMSD 0.42 Å
- 3NDQ chain A against the predicted model P23193: TM-score 0.99, RMSD 0.42 Å
- 9EH1 chain S against the predicted model P23193: TM-score 0.99, RMSD 0.57 Å
- 9EH2 chain S against the predicted model P23193: TM-score 0.98, RMSD 0.70 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.