MolNFT v1 · #171750 · protein

14-3-3 zeta chimera with 18E6 and fusicoccin

6ZFG · 14-3-3 protein ZETA/DELTA,PROTEIN E6: “14-3-3 zeta chimera with 18E6 and fusicoccin”. X-ray diffraction, 1 ligand (FSC), 3 pockets (best druggability 0.58). MolNFT v1 #171750 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6ZFG
Type: protein
Length: 482 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 14-3-3 protein ZETA/DELTA,PROTEIN E6
UniProt: P63104, P06463
Ligands: FSC
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	14-3-3 protein ZETA/DELTA,PROTEIN E6	protein	240	80% helix, 0% strand	P63104, P06463
B	14-3-3 protein ZETA/DELTA,PROTEIN E6	protein	242	80% helix, 0% strand	P63104, P06463

Ligands and binding sites

FSC · Fusicoccin · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	332	0.58	0.76	28	FSC
2	312	0.58	0.77	30	FSC
3	303	0.52	0.74	26	GOL

Interfaces

1 interface between chains.

A–B · 906 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

6ZFG · 14-3-3 zeta chimera with 18E6 and fusicoccin · the same entry in another collection · chain A against A, TM-score 1.00
P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63104
Every structure of UniProt P06463
Elsewhere: RCSB PDB 6ZFG · PDBe 6ZFG · UniProt P63104 · UniProt P06463

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