MolNFT v1 · #171674 · protein

Syk kinase domain in complex with azabenzimidazole inhibitor 3

6ZCS · Tyrosine-protein kinase syk: “Syk kinase domain in complex with azabenzimidazole inhibitor 3”. X-ray diffraction, 1 ligand (QFE), 1 pocket (best druggability 0.62). MolNFT v1 #171674 on GenesisL1: 3D structure, binding sites and…

PDB: 6ZCS
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase syk
EC: 2.7.10.2
UniProt: P43405
Ligands: QFE
Pockets: 1 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase syk (EC 2.7.10.2)	protein	269	41% helix, 23% strand	P43405

Ligands and binding sites

QFE · (3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.62	0.80	32	QFE

Compared structures

6ZCS · SYK Kinase domain in complex with azabenzimidazole inhibitor 3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43405
Elsewhere: RCSB PDB 6ZCS · PDBe 6ZCS · UniProt P43405

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