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Ligand · QFE

QFE · (3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine

QFE, (3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine (C23 H24 N8 O, 428.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
QFE
Formula
C23 H24 N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

QFE in 2 structures; the first of them:

  • 6ZCS · SYK Kinase domain in complex with azabenzimidazole inhibitor 3 · QFE A701 · binds LEU377, GLY378, SER379, PHE382, VAL385, ALA400, LYS402, VAL433 and 13 more
  • 6ZCS · Syk kinase domain in complex with azabenzimidazole inhibitor 3 · QFE A701 · binds LEU377, SER379, VAL385, ALA400, LYS402, MET448, GLU449, MET450 and 9 more

Residues it binds most

LEU 2, ALA 2, GLU 2, MET 2, SER 2, GLY 2, VAL 2, ARG 2, ASN 2, ASP 2 (residue and the binding sites it lines).

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