MolNFT v1 · #171520 · protein
Inhibitory human GTP cyclohydrolase I - gfrp complex
6Z85 · GTP cyclohydrolase 1: “Inhibitory human GTP cyclohydrolase I - gfrp complex”. Electron microscopy, 2 ligands (HBI, ZN), 20 pockets (best druggability 0.88). MolNFT v1 #171520 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6Z85
- Type
- protein
- Length
- 2,360 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase 1; GTP cyclohydrolase 1 feedback regulatory protein
- EC
- 3.5.4.16
- UniProt
- P30793, P30047
- Ligands
- HBI, ZN
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, B, E, G, H, I, J, F | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 155 | 41% helix, 28% strand | P30793 |
| K, L, M, N, O, P, Q, R, S, T | GTP cyclohydrolase 1 feedback regulatory protein | protein | 81 | 20% helix, 36% strand | P30047 |
Ligands and binding sites
- HBI · 7,8-dihydrobiopterin · ligand · 10 copies · chains A, E, C, B, D, G, F, H, I, J
- ZN · Zinc ion · metal · 10 copies · chains A, C, D, B, E, G, H, I, J, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 970 | 0.88 | 0.90 | 106 | HBI |
| 2 | 701 | 0.87 | 0.91 | 91 | HBI |
| 3 | 92 | 0.78 | 0.98 | 22 | empty |
| 4 | 99 | 0.78 | 0.97 | 22 | empty |
| 5 | 92 | 0.77 | 0.97 | 22 | empty |
Interfaces
55 interfaces between chains.
- D–H · 1506 Ų buried · 7 hydrogen bonds · protein-protein
- C–I · 1502 Ų buried · 8 hydrogen bonds · protein-protein
- E–G · 1494 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 1492 Ų buried · 6 hydrogen bonds · protein-protein
- B–J · 1487 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6Z85 · inhibitory human GTP cyclohydrolase I - GFRP complex · the same entry in another collection · chain T against T, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30793
- Every structure of UniProt P30047
- Elsewhere: RCSB PDB 6Z85 · PDBe 6Z85 · UniProt P30793 · UniProt P30047
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