MolNFT v1 · #171517 · protein
Stimulatory human GTP cyclohydrolase I - gfrp complex
6Z80 · GTP cyclohydrolase 1: “Stimulatory human GTP cyclohydrolase I - gfrp complex”. Electron microscopy, 3 ligands (PHE, 8GT, ZN), 20 pockets (best druggability 0.83). MolNFT v1 #171517 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6Z80
- Type
- protein
- Length
- 2,650 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase 1; GTP cyclohydrolase 1 feedback regulatory protein
- EC
- 3.5.4.16
- UniProt
- P30793, P30047
- Ligands
- PHE, 8GT, ZN
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, E, G, H, I, J, F, D | GTP cyclohydrolase 1 (EC 3.5.4.16) | protein | 182 | 43% helix, 28% strand | P30793 |
| L, K, N, M, O, P, Q, R, S, T | GTP cyclohydrolase 1 feedback regulatory protein | protein | 83 | 22% helix, 39% strand | P30047 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · 10 copies · chains L, C, M, B, K, E, N, O, D, A, G, P, Q, H, R, I, S, J, T, F
- 8GT · 8-oxo-guanosine-5'-triphosphate · ligand · 10 copies · chains A, B, F, C, J, E, G, H, I, D
- ZN · Zinc ion · metal · 10 copies · chains A, B, C, E, G, H, I, J, F, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 332 | 0.83 | 0.93 | 40 | empty |
| 2 | 476 | 0.83 | 0.90 | 74 | PHE |
| 3 | 396 | 0.82 | 0.91 | 40 | empty |
| 4 | 92 | 0.78 | 0.98 | 22 | empty |
| 5 | 82 | 0.77 | 0.98 | 22 | empty |
Interfaces
65 interfaces between chains.
- H–D · 1931 Ų buried · 10 hydrogen bonds · protein-protein
- B–J · 1928 Ų buried · 12 hydrogen bonds · protein-protein
- E–G · 1925 Ų buried · 10 hydrogen bonds · protein-protein
- C–I · 1922 Ų buried · 10 hydrogen bonds · protein-protein
- A–F · 1917 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6Z80 · stimulatory human GTP cyclohydrolase I - GFRP complex · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30793
- Every structure of UniProt P30047
- Elsewhere: RCSB PDB 6Z80 · PDBe 6Z80 · UniProt P30793 · UniProt P30047
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