MolNFT v1 · #171003 · protein
Crystal structure of the camp-dependent protein kinase a cocrystallized with pki (5-24). soaking of aminofasudil and displacing it with the fragment isoquinoline.
6YPP: “Crystal structure of the camp-dependent protein kinase a cocrystallized with pki (5-24). soaking of…”. X-ray diffraction, 1 ligand (ISQ). MolNFT v1 #171003 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6YPP
- Type
- protein
- Length
- 353 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P25321, P63248
- Ligands
- ISQ
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 337 | — | P25321 |
| B | — | protein | 16 | — | P63248 |
Ligands and binding sites
- ISQ · Isoquinoline · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6YPP · Crystal structure of the cAMP-dependent protein kinase A cocrystallized with PKI (5-24).… · the same entry in another collection · chain A against A, TM-score 1.00
- P63248 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase inhibitor alpha… · a predicted model of the same protein · chain B against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25321
- Every structure of UniProt P63248
- Elsewhere: RCSB PDB 6YPP · PDBe 6YPP · UniProt P25321 · UniProt P63248
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