Structure of the AMPA receptor GLUA2O ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-amino-2'-carboxyethyl)-5,7- DIHYDROFURO[3,4-D]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).

Ligands and binding sites

• PVK · (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione · ligand · chains A
• LI · Lithium ion · metal · chains A
• SO4 · Sulfate ion · ion · 6 copies · chains A
• CL · Chloride ion · ion · chains A
• GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 6YK5 · Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
• P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 6YK5 · PDBe 6YK5 · UniProt P19491