MolNFT v1 · #17014 · protein

Crystal structure of SULA:FTSZ from pseudomonas aeruginosa

1OFU · Cell division protein ftsz: “Crystal structure of SULA:FTSZ from pseudomonas aeruginosa”. X-ray diffraction, 1 ligand (GDP), 14 pockets (best druggability 0.51). MolNFT v1 #17014 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1OFU
Type: protein
Length: 851 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein ftsz; Hypothetical protein PA3008
UniProt: P47204, Q9HZJ8
Ligands: GDP
Pockets: 14 · best druggability 0.51

Structure

x-ray diffraction · 3 distinct chains · 44% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cell division protein ftsz	protein	307	47% helix, 25% strand	P47204
X	Hypothetical protein PA3008	protein	118	42% helix, 25% strand	Q9HZJ8
Y	Hypothetical protein PA3008	protein	119	41% helix, 24% strand	Q9HZJ8

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.51	0.80	19	empty
2	113	0.51	0.81	19	empty
3	146	0.50	0.79	36	GDP
4	137	0.49	0.79	32	GDP
5	155	0.47	0.77	26	empty

Interfaces

3 interfaces between chains.

X–Y · 823 Å² buried · 14 hydrogen bonds · protein-protein
A–X · 806 Å² buried · 9 hydrogen bonds · protein-protein
B–Y · 802 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1OFU · Crystal structure of SulA:FtsZ from Pseudomonas aeruginosa · the same entry in another collection · chain Y against Y, TM-score 1.00
P47204 · AlphaFold monomer V2.0 prediction for cell division protein ftsz (P47204) · a predicted model of the same protein · chain B against A, TM-score 0.98
Q9HZJ8 · AlphaFold monomer V2.0 prediction for cell division inhibitor sula (Q9HZJ8) · a predicted model of the same protein · chain Y against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P47204
Every structure of UniProt Q9HZJ8
Elsewhere: RCSB PDB 1OFU · PDBe 1OFU · UniProt P47204 · UniProt Q9HZJ8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.