Research workbench
Crystal structure of SULA:FTSZ from pseudomonas aeruginosa
Analyse Crystal structure of SULA:FTSZ from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OFU
- Type
- protein
- Length
- 851 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein ftsz; Hypothetical protein PA3008
- UniProt
- P47204, Q9HZJ8
- Ligands
- GDP
- Pockets
- 14 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cell division protein ftsz | protein | 307 | 47% helix, 25% strand | P47204 |
| X | Hypothetical protein PA3008 | protein | 118 | 42% helix, 25% strand | Q9HZJ8 |
| Y | Hypothetical protein PA3008 | protein | 119 | 41% helix, 24% strand | Q9HZJ8 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.51 | 0.80 | 19 | empty |
| 2 | 113 | 0.51 | 0.81 | 19 | empty |
| 3 | 146 | 0.50 | 0.79 | 36 | GDP |
| 4 | 137 | 0.49 | 0.79 | 32 | GDP |
| 5 | 155 | 0.47 | 0.77 | 26 | empty |
Interfaces
3 interfaces between chains.
- X–Y · 823 Ų buried · 14 hydrogen bonds · protein-protein
- A–X · 806 Ų buried · 9 hydrogen bonds · protein-protein
- B–Y · 802 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1OFU · Crystal structure of SulA:FtsZ from Pseudomonas aeruginosa · the same entry in another collection · chain Y against Y, TM-score 1.00
- P47204 · AlphaFold monomer V2.0 prediction for cell division protein ftsz (P47204) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q9HZJ8 · AlphaFold monomer V2.0 prediction for cell division inhibitor sula (Q9HZJ8) · a predicted model of the same protein · chain Y against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47204
- Every structure of UniProt Q9HZJ8
- Elsewhere: RCSB PDB 1OFU · PDBe 1OFU · UniProt P47204 · UniProt Q9HZJ8
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