MolNFT v1 · #16972 · protein
Conformational variability in the refined structure of the chaperonin groel at 2.8 ångström resolution
1OEL · Groel (HSP60 class): “Conformational variability in the refined structure of the chaperonin groel at 2.8 ångström resolution”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #16972 on GenesisL1: 3D structure…
- PDB
- 1OEL
- Type
- protein
- Length
- 3,668 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Groel (HSP60 class)
- UniProt
- P0A6F5
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Groel (HSP60 class) | protein | 524 | 54% helix, 18% strand | P0A6F5 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 872 | 0.79 | 0.82 | 94 | empty |
| 2 | 1127 | 0.78 | 0.80 | 94 | empty |
| 3 | 1147 | 0.78 | 0.80 | 99 | empty |
| 4 | 524 | 0.73 | 0.82 | 59 | empty |
| 5 | 640 | 0.73 | 0.80 | 58 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1698 Ų buried · 29 hydrogen bonds · protein-protein
- E–F · 1659 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1651 Ų buried · 25 hydrogen bonds · protein-protein
- F–G · 1650 Ų buried · 28 hydrogen bonds · protein-protein
- D–E · 1642 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1OEL · Conformational variability in the refined structure of the chaperonin groel at 2.8… · the same entry in another collection · chain G against G, TM-score 1.00
- P0A6F5 · AlphaFold monomer V2.0 prediction for 60 kda chaperonin (P0A6F5) · a predicted model of the same protein · chain C against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6F5
- Elsewhere: RCSB PDB 1OEL · PDBe 1OEL · UniProt P0A6F5
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