Research workbench
Conformational variability in the refined structure of the chaperonin groel at 2.8 ångström resolution
Analyse Conformational variability in the refined structure of the chaperonin groel at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OEL
- Type
- protein
- Length
- 3,668 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Groel (HSP60 class)
- UniProt
- P0A6F5
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Groel (HSP60 class) | protein | 524 | 54% helix, 18% strand | P0A6F5 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 872 | 0.79 | 0.82 | 94 | empty |
| 2 | 1127 | 0.78 | 0.80 | 94 | empty |
| 3 | 1147 | 0.78 | 0.80 | 99 | empty |
| 4 | 524 | 0.73 | 0.82 | 59 | empty |
| 5 | 640 | 0.73 | 0.80 | 58 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1698 Ų buried · 29 hydrogen bonds · protein-protein
- E–F · 1659 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1651 Ų buried · 25 hydrogen bonds · protein-protein
- F–G · 1650 Ų buried · 28 hydrogen bonds · protein-protein
- D–E · 1642 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1OEL · Conformational variability in the refined structure of the chaperonin groel at 2.8… · the same entry in another collection · chain G against G, TM-score 1.00
- P0A6F5 · AlphaFold monomer V2.0 prediction for 60 kda chaperonin (P0A6F5) · a predicted model of the same protein · chain C against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6F5
- Elsewhere: RCSB PDB 1OEL · PDBe 1OEL · UniProt P0A6F5
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