MolNFT v1 · #168987 · protein

SOX2 bound to importin-alpha 2

6WX7 · Importin subunit alpha-1: “SOX2 bound to importin-alpha 2”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #168987 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WX7
Type: protein
Length: 439 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Transcription factor sox-2
UniProt: P52293, P48431
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	426	73% helix, 0% strand	P52293
B	Transcription factor sox-2	protein	13	0% helix, 0% strand	P48431

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.47	0.77	33	empty
2	75	0.42	0.79	12	empty

Interfaces

1 interface between chains.

A–B · 1128 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

6WX7 · SOX2 bound to Importin-alpha 2 · the same entry in another collection · chain A against A, TM-score 1.00
P48431 · AlphaFold monomer V2.0 prediction for transcription factor sox-2 (P48431) · a predicted model of the same protein · chain B against A, TM-score 0.32

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt P48431
Elsewhere: RCSB PDB 6WX7 · PDBe 6WX7 · UniProt P52293 · UniProt P48431

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