UniProt P48431
Transcription factor SOX-2 (P48431)
Transcription factor SOX-2 (UniProt P48431): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P48431
- Protein
- Transcription factor SOX-2
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
13 records of P48431 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1O4X | Ternary complex of the DNA binding domains of the OCT1 and SOX2 transcription factors with a 19MER… | solution nmr | B | — | — |
| 1O4X | Ternary complex of the DNA binding domains of the OCT1 and SOX2 transcription factors with a 19MER… | solution nmr | B | — | — |
| 2LE4 | Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2 | solution nmr | A | — | — |
| 2LE4 | Solution structure of the hmg box DNA-binding domain of human stem cell transcription factor SOX2 | solution nmr | A | — | — |
| 6T7B | Structure of human Sox2 transcription factor in complex with a nucleosome | electron microscopy | K | — | 3 (best 0.58) |
| 6T7B | Structure of human SOX2 transcription factor in complex with a nucleosome | electron microscopy | K | — | — |
| 6T90 | OCT4-SOX2-bound nucleosome - SHL-6 | electron microscopy | L | PTD | 1 (best 0.75) |
| 6T90 | OCT4-SOX2-bound nucleosome - shl-6 | electron microscopy | L | PTD | — |
| 6WX7 | SOX2 bound to importin-alpha 2 | x-ray diffraction | B | — | — |
| 6WX8 | SOX2 bound to importin-alpha 3 | x-ray diffraction | B, D | SO4 | — |
| 6WX9 | SOX2 bound to importin-alpha 5 | x-ray diffraction | B | — | — |
| 6YOV | OCT4-SOX2-bound nucleosome - SHL+6 | electron microscopy | L | — | — |
| P48431 | AlphaFold monomer V2.0 prediction for transcription factor sox-2 (P48431) | predicted | A | — | 3 (best 0.38) |
Ligands
Experiment against prediction
- 6T90 chain L against the predicted model P48431: TM-score 0.94, RMSD 0.82 Å
- 6T90 chain L against the predicted model P48431: TM-score 0.94, RMSD 0.82 Å
- 6YOV chain L against the predicted model P48431: TM-score 0.93, RMSD 0.85 Å
- 6T7B chain K against the predicted model P48431: TM-score 0.93, RMSD 0.89 Å
- 6T7B chain K against the predicted model P48431: TM-score 0.93, RMSD 0.89 Å
- 1O4X chain B against the predicted model P48431: TM-score 0.93, RMSD 0.97 Å
- 1O4X chain B against the predicted model P48431: TM-score 0.93, RMSD 0.97 Å
- 6WX8 chain D against the predicted model P48431: TM-score 0.75, RMSD 1.72 Å
- 6WX8 chain B against the predicted model P48431: TM-score 0.75, RMSD 1.73 Å
- 2LE4 chain A against the predicted model P48431: TM-score 0.51, RMSD 3.04 Å
Elsewhere
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