MolNFT v1 · #168409 · protein
The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human
6WFV · Multifunctional procollagen lysine hydroxylase and…: “The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human”. X-ray diffraction, 3 ligands (UDP, MG, MN), 1 pocket (best druggability 0.68). MolNFT…
- PDB
- 6WFV
- Type
- protein
- Length
- 233 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- EC
- 1.14.11.4, 2.4.1.50, 2.4.1.66
- UniProt
- O60568
- Ligands
- UDP, MG, MN
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (EC 1.14.11.4, 2.4.1.50, 2.4.1.66) | protein | 233 | 35% helix, 25% strand | O60568 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- MN · Manganese (II) ion · metal · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.68 | 0.80 | 37 | MG, UDP |
Compared structures
- 6WFV · The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human · the same entry in another collection · chain A against A, TM-score 1.00
- O60568 · AlphaFold monomer V2.0 prediction for multifunctional procollagen lysine hydroxylase and… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60568
- Elsewhere: RCSB PDB 6WFV · PDBe 6WFV · UniProt O60568
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