UniProt O60568
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (O60568)
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (UniProt O60568), EC 1.14.11.4, 2.4.1.50: 24 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 46 pockets. Binding sites, druggability and experiment…
- UniProt
- O60568
- Protein
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
- EC
- 1.14.11.4, 2.4.1.50, 2.4.1.66
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 46 · 11 records with a druggable one
Structures
25 records of O60568 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6FXK | Crystal structure of full-length human lysyl hydroxylase LH3 | x-ray diffraction | A | NAG, AKG, FE2 | — |
| 6FXM | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Mn2+ | x-ray diffraction | A | NAG, AKG, FE2, MN | 4 (best 0.72) |
| 6FXM | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with MN2+ | x-ray diffraction | A | NAG, AKG, FE2, MN | — |
| 6FXR | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Gal | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | 5 (best 0.74) |
| 6FXR | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp-gal | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | — |
| 6FXT | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Glc | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | 4 (best 0.74) |
| 6FXT | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp-glc | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | — |
| 6FXX | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Gal… | x-ray diffraction | A | NAG, HG, AKG, UDP, MN, FE2 | 4 (best 0.77) |
| 6FXX | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp-gal… | x-ray diffraction | A | NAG, HG, AKG, UDP, MN, FE2 | — |
| 6FXY | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Gal… | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | — |
| 6FXY | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp-gal… | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | — |
| 6TE3 | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP | x-ray diffraction | A | NAG, AKG, FE2, MN | 4 (best 0.70) |
| 6TE3 | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp | x-ray diffraction | A | NAG, AKG, FE2, MN | — |
| 6TEC | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Xylose | x-ray diffraction | A | NAG, UDX, AKG, FE2, MN | 3 (best 0.77) |
| 6TEC | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+, udp-xylose | x-ray diffraction | A | NAG, UDX, AKG, FE2, MN | — |
| 6TES | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+… | x-ray diffraction | A | NAG, AKG, FE2, MN, UGA | 6 (best 0.78) |
| 6TES | Crystal structure of full-length human lysyl hydroxylase LH3 - cocrystal with FE2+, MN2+… | x-ray diffraction | A | NAG, AKG, FE2, MN, UGA | — |
| 6TEU | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Val80Lys mutant - Cocrystal with… | x-ray diffraction | A | NAG, AKG, FE2, MN | 4 (best 0.71) |
| 6TEU | Crystal structure of full-length human lysyl hydroxylase LH3 - VAL80LYS mutant - cocrystal with… | x-ray diffraction | A | NAG, AKG, FE2, MN | — |
| 6TEX | Crystal structure of full-length human lysyl hydroxylase LH3 - VAL80LYS mutant - cocrystal with… | x-ray diffraction | A | NAG, AKG, UDP, FE2, MN | — |
| 6TEZ | Crystal structure of full-length human lysyl hydroxylase LH3 - VAL80LYS mutant - cocrystal with… | x-ray diffraction | A | NAG, UGA, AKG, FE2, MN | — |
| 6WFV | The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human | x-ray diffraction | A | MN, MG, UDP | 1 (best 0.68) |
| 6WFV | The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human | x-ray diffraction | A | MN, MG, UDP | — |
| 8ONE | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with… | x-ray diffraction | A | NAG, AKG, FE2, MN, UPG | 5 (best 0.75) |
| O60568 | AlphaFold monomer V2.0 prediction for multifunctional procollagen lysine hydroxylase and… | predicted | A | — | 6 (best 0.73) |
Ligands
- MN · Manganese (II) ion · in 23 records
- AKG · 2-oxoglutaric acid · in 22 records
- FE2 · Fe (II) ion · in 22 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 22 records
- UDP · Uridine-5'-diphosphate · in 11 records
- UGA · Uridine-5'-diphosphate-glucuronic acid · in 3 records
- HG · Mercury (II) ion · in 2 records
- MG · Magnesium ion · in 2 records
- UDX · Uridine-5'-diphosphate-xylopyranose · in 2 records
- UPG · Uridine-5'-diphosphate-glucose · in 1 record
Experiment against prediction
- 6FXK chain A against the predicted model O60568: TM-score 0.99, RMSD 0.93 Å
- 6FXM chain A against the predicted model O60568: TM-score 0.99, RMSD 1.28 Å
- 6FXM chain A against the predicted model O60568: TM-score 0.99, RMSD 1.28 Å
- 8ONE chain A against the predicted model O60568: TM-score 0.98, RMSD 1.40 Å
- 6TEU chain A against the predicted model O60568: TM-score 0.98, RMSD 1.14 Å
- 6TEU chain A against the predicted model O60568: TM-score 0.98, RMSD 1.14 Å
- 6FXY chain A against the predicted model O60568: TM-score 0.98, RMSD 1.28 Å
- 6FXY chain A against the predicted model O60568: TM-score 0.98, RMSD 1.28 Å
- 6TES chain A against the predicted model O60568: TM-score 0.98, RMSD 1.29 Å
- 6TES chain A against the predicted model O60568: TM-score 0.98, RMSD 1.29 Å
Elsewhere
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