MolNFT v1 · #168321 · protein
Human open state TMEM175 in kcl
6WC9 · ENDOSOMAL/LYSOSOMAL potassium channel TMEM175: “Human open state TMEM175 in kcl”. Electron microscopy, 1 ligand (K), 12 pockets (best druggability 0.79). MolNFT v1 #168321 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6WC9
- Type
- protein
- Length
- 734 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOSOMAL/LYSOSOMAL potassium channel TMEM175
- UniProt
- Q9BSA9
- Ligands
- K
- Pockets
- 12 · best druggability 0.79
Structure
electron microscopy · 1 distinct chain · 78% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 | protein | 367 | 78% helix, 2% strand | Q9BSA9 |
Ligands and binding sites
- K · Potassium ion · metal · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 721 | 0.79 | 0.84 | 78 | K |
| 2 | 360 | 0.62 | 0.77 | 42 | empty |
| 3 | 118 | 0.56 | 0.84 | 24 | empty |
| 4 | 242 | 0.53 | 0.76 | 26 | empty |
| 5 | 117 | 0.52 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 3151 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BSA9
- Elsewhere: RCSB PDB 6WC9 · PDBe 6WC9 · UniProt Q9BSA9
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