MolNFT v1 · #168206 · protein
Structure of membrane protein with ions
6W8P · ENDOSOMAL/LYSOSOMAL potassium channel TMEM175: “Structure of membrane protein with ions”. Electron microscopy, 1 ligand (K), 20 pockets (best druggability 0.81). MolNFT v1 #168206 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6W8P
- Type
- protein
- Length
- 844 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOSOMAL/LYSOSOMAL potassium channel TMEM175
- UniProt
- Q9BSA9
- Ligands
- K
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 | protein | 418 | 73% helix, 0% strand | Q9BSA9 |
| B | ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 | protein | 426 | 75% helix, 0% strand | Q9BSA9 |
Ligands and binding sites
- K · Potassium ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 391 | 0.81 | 0.90 | 51 | empty |
| 2 | 139 | 0.77 | 0.95 | 26 | empty |
| 3 | 328 | 0.70 | 0.83 | 51 | K |
| 4 | 68 | 0.65 | 0.92 | 21 | K |
| 5 | 317 | 0.64 | 0.80 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 3228 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BSA9
- Elsewhere: RCSB PDB 6W8P · PDBe 6W8P · UniProt Q9BSA9
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