MolNFT v1 · #167798 · protein
Structure of the human clamp loader (replication factor C, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, PCNA)
6VVO: “Structure of the human clamp loader (replication factor C, rfc) bound to the sliding clamp (proliferating…”. Electron microscopy, 3 ligands (AGS, ADP, MG). MolNFT v1 #167798 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6VVO
- Type
- protein
- Length
- 2,493 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P35251, P35250, P40937, P35249, P40938, P12004
- Ligands
- AGS, ADP, MG
Structure
electron microscopy · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 448 | — | P35251 |
| B | — | protein | 316 | — | P35250 |
| C | — | protein | 312 | — | P40937 |
| D | — | protein | 304 | — | P35249 |
| E | — | protein | 346 | — | P40938 |
| F | — | protein | 254 | — | P12004 |
| G | — | protein | 257 | — | P12004 |
| H | — | protein | 256 | — | P12004 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · 4 copies · chains A, B, C, D
- ADP · Adenosine-5'-diphosphate · ligand · chains E
- MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VVO · Structure of the human clamp loader (Replication Factor C, RFC) bound to the sliding… · the same entry in another collection · chain H against H, TM-score 1.00
- P40938 · AlphaFold monomer V2.0 prediction for replication factor C subunit 3 (P40938) · a predicted model of the same protein · chain E against A, TM-score 0.98
- P35250 · AlphaFold monomer V2.0 prediction for replication factor C subunit 2 (P35250) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P40937 · AlphaFold monomer V2.0 prediction for replication factor C subunit 5 (P40937) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P35249 · AlphaFold monomer V2.0 prediction for replication factor C subunit 4 (P35249) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35251
- Every structure of UniProt P35250
- Every structure of UniProt P40937
- Every structure of UniProt P35249
- Every structure of UniProt P40938
- Every structure of UniProt P12004
- Elsewhere: RCSB PDB 6VVO · PDBe 6VVO · UniProt P35251 · UniProt P35250 · UniProt P40937 · UniProt P35249 · UniProt P40938 · UniProt P12004
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