MolNFT v1 · #167397 · protein

Crystal structure of wild-type KRAS4B (gmppnp-bound) in complex with RAS-binding domain (rbd) of RAF1/CRAF

6VJJ: “Crystal structure of wild-type KRAS4B (gmppnp-bound) in complex with RAS-binding domain (rbd) of RAF1/CRAF”. X-ray diffraction, 3 ligands (GNP, MG, CL). MolNFT v1 #167397 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VJJ
Type: protein
Length: 245 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P01116, P04049
Ligands: GNP, MG, CL

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	168	—	P01116
B	—	protein	77	—	P04049

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A
CL · Chloride ion · ion · 3 copies · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6VJJ · Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain… · the same entry in another collection · chain A against A, TM-score 1.00
P04049 · AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01116
Every structure of UniProt P04049
Elsewhere: RCSB PDB 6VJJ · PDBe 6VJJ · UniProt P01116 · UniProt P04049

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