MolNFT v1 · #167281 · protein
Crystal structure of human cytosolic isocitrate dehydrogenase (IDH1) R132H mutant in complex with NADPH and agi-15056
6VG0: “Crystal structure of human cytosolic isocitrate dehydrogenase (IDH1) R132H mutant in complex with NADPH and…”. X-ray diffraction, 2 ligands (NDP, QWM). MolNFT v1 #167281 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VG0
- Type
- protein
- Length
- 1,232 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75874
- Ligands
- NDP, QWM
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 413 | — | O75874 |
| B | — | protein | 415 | — | O75874 |
| C | — | protein | 404 | — | O75874 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 3 copies · chains A, B, C
- QWM · N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine · ligand · 2 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VG0 · CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75874
- Elsewhere: RCSB PDB 6VG0 · PDBe 6VG0 · UniProt O75874
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