GL1X · GenesisL1 explorer

Ligand · QWM

QWM · N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine

QWM, N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine (C19 H23 F3 N6, 392.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
QWM
Formula
C19 H23 F3 N6
Class
ligand
Structures
2
PDB entries
1

Binding sites

QWM in 2 structures; the first of them:

  • 6VG0 · CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN… · QWM B501 · binds VAL121, TRP124, ILE251, VAL255, MET259, TYR272, ASP273, VAL276 and 14 more
  • 6VG0 · Crystal structure of human cytosolic isocitrate dehydrogenase (IDH1) R132H mutant in… · QWM B501 · binds TRP124, VAL255, MET259, TYR272, ASP273, VAL276, GLN277, SER280 and 10 more

Residues it binds most

VAL 4, ASP 4, GLN 4, MET 4, SER 4, TRP 4, TYR 4, ILE 4, ALA 1 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate

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