MolNFT v1 · #167123 · protein
Crystal structure of recombinant mutant H180R of human fumarase
6VBE · Fumarate hydratase, mitochondrial: “Crystal structure of recombinant mutant H180R of human fumarase”. X-ray diffraction, 12 pockets (best druggability 0.50). MolNFT v1 #167123 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6VBE
- Type
- protein
- Length
- 924 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fumarate hydratase, mitochondrial
- EC
- 4.2.1.2
- UniProt
- P07954
- Pockets
- 12 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fumarate hydratase, mitochondrial (EC 4.2.1.2) | protein | 462 | 62% helix, 8% strand | P07954 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.50 | 0.76 | 37 | TLA |
| 2 | 80 | 0.49 | 0.83 | 18 | empty |
| 3 | 61 | 0.44 | 0.83 | 14 | empty |
| 4 | 76 | 0.41 | 0.79 | 17 | empty |
| 5 | 67 | 0.41 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3199 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 6VBE · Crystal structure of recombinant mutant H180R of human fumarase · the same entry in another collection · chain A against A, TM-score 1.00
- P07954 · AlphaFold monomer V2.0 prediction for fumarate hydratase, mitochondrial (P07954) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07954
- Elsewhere: RCSB PDB 6VBE · PDBe 6VBE · UniProt P07954
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