UniProt P07954
Fumarate hydratase, mitochondrial (P07954)
Fumarate hydratase, mitochondrial (UniProt P07954), EC 4.2.1.2: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P07954
- Protein
- Fumarate hydratase, mitochondrial
- EC
- 4.2.1.2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 1 record with a druggable one
Structures
11 records of P07954 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3E04 | Crystal structure of human fumarate hydratase | x-ray diffraction | A, B, C, D | — | — |
| 3E04 | Crystal structure of human fumarate hydratase | x-ray diffraction | A, B, C, D | — | — |
| 5D6B | Human fumarase (wild type) | x-ray diffraction | A | — | — |
| 5D6B | Human fumarase (wild type) | x-ray diffraction | A | — | — |
| 5UPP | Crystal structure of human fumarate hydratase | x-ray diffraction | A, B | — | — |
| 6EBT | Crystal structure of recombinant mutant N107T of human fumarase | x-ray diffraction | A, B | — | — |
| 6V8F | Crystal structure of recombinat mutant Q185R of human fumarase | x-ray diffraction | A, B | SO4, CL | 12 (best 0.58) |
| 6V8F | Crystal structure of recombinat mutant Q185R of human fumarase | x-ray diffraction | A, B | SO4, CL | — |
| 6VBE | Crystal structure of recombinant mutant H180R of human fumarase | x-ray diffraction | A, B | — | — |
| 7LUB | Crystal structure of recombinant human fumarase in complex with D-2- amino-3-phosphono-propionic… | x-ray diffraction | A, B | APO | — |
| P07954 | AlphaFold monomer V2.0 prediction for fumarate hydratase, mitochondrial (P07954) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5UPP chain A against the predicted model P07954: TM-score 1.00, RMSD 0.30 Å
- 5UPP chain B against the predicted model P07954: TM-score 1.00, RMSD 0.33 Å
- 6V8F chain A against the predicted model P07954: TM-score 1.00, RMSD 0.43 Å
- 6V8F chain A against the predicted model P07954: TM-score 1.00, RMSD 0.43 Å
- 5D6B chain A against the predicted model P07954: TM-score 1.00, RMSD 0.44 Å
- 5D6B chain A against the predicted model P07954: TM-score 1.00, RMSD 0.44 Å
- 6EBT chain B against the predicted model P07954: TM-score 1.00, RMSD 0.50 Å
- 6V8F chain B against the predicted model P07954: TM-score 1.00, RMSD 0.52 Å
- 6V8F chain B against the predicted model P07954: TM-score 1.00, RMSD 0.52 Å
- 6VBE chain A against the predicted model P07954: TM-score 1.00, RMSD 0.51 Å
Elsewhere
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