MolNFT v1 · #167088 · protein

Fanconi anemia id complex

6VAD · Fanconi anemia, complementation group I: “Fanconi anemia id complex”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #167088 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VAD
Type: protein
Length: 2,321 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia, complementation group I; Fanconi anemia group D2 protein
UniProt: B7ZMF2, Q9BXW9
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 2 distinct chains · 68% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fanconi anemia, complementation group I	protein	1168	68% helix, 1% strand	B7ZMF2
B	Fanconi anemia group D2 protein	protein	1153	68% helix, 2% strand	Q9BXW9

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	918	0.80	0.82	97	empty
2	1152	0.79	0.81	107	empty
3	130	0.75	0.94	35	empty
4	71	0.74	0.97	14	empty
5	463	0.66	0.78	43	empty

Interfaces

1 interface between chains.

A–B · 2542 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

6VAD · Fanconi Anemia ID complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9BXW9 · AlphaFold monomer V2.0 prediction for fanconi anemia group D2 protein (Q9BXW9) · a predicted model of the same protein · chain B against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B7ZMF2
Every structure of UniProt Q9BXW9
Elsewhere: RCSB PDB 6VAD · PDBe 6VAD · UniProt B7ZMF2 · UniProt Q9BXW9

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