MolNFT v1 · #167011 · protein

Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1

6V83: “Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1”. X-ray diffraction, 1 ligand (CAZ), 1 pocket (best druggability 0.33). MolNFT v1 #167011 on GenesisL1: 3D structure, binding sites and…

PDB: 6V83
Type: protein
Length: 261 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: Q9L5C7
Ligands: CAZ
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactamase (EC 3.5.2.6)	protein	261	44% helix, 20% strand	Q9L5C7

Ligands and binding sites

CAZ · Acylated ceftazidime · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.33	0.75	20	CAZ

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

6V83 · Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9L5C7
Elsewhere: RCSB PDB 6V83 · PDBe 6V83 · UniProt Q9L5C7

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