UniProt Q9L5C7
Beta-lactamase (Q9L5C7)
Beta-lactamase (UniProt Q9L5C7), EC 3.5.2.6: 44 experimental structures on GenesisL1, 9 ligands bound, 64 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9L5C7
- Protein
- Beta-lactamase
- EC
- 3.5.2.6
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 64 · 8 records with a druggable one
Structures
44 records of Q9L5C7 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YLT | Atomic resolution structure of CTX-M-14 beta-lactamase | x-ray diffraction | A | — | — |
| 1YLT | Atomic resolution structure of ctx-M-14 beta-lactamase | x-ray diffraction | A | — | — |
| 1YLY | X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with ceftazidime-like boronic… | x-ray diffraction | A, B | — | — |
| 1YLY | X-ray crystallographic structure of ctx-M-9 beta-lactamase complexed with ceftazidime-like boronic… | x-ray diffraction | A, B | — | — |
| 1YLZ | X-ray crystallographic structure of CTX-M-14 beta-lactamase complexed with ceftazidime-like boronic… | x-ray diffraction | A, B | — | — |
| 1YLZ | X-ray crystallographic structure of ctx-M-14 beta-lactamase complexed with ceftazidime-like boronic… | x-ray diffraction | A, B | — | — |
| 4XXR | Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in… | x-ray diffraction | A, B | — | — |
| 4XXR | Atomic resolution X-ray crystal structure of a ruthenocene conjugated beta-lactam antibiotic in… | x-ray diffraction | A, B | — | — |
| 5TW6 | CTX-M-14 P167S:E166A mutant with acylated ceftazidime molecule | x-ray diffraction | A | CAZ | 2 (best 0.63) |
| 5TW6 | Ctx-M-14 P167S:E166A mutant with acylated ceftazidime molecule | x-ray diffraction | A | CAZ | — |
| 5TWD | CTX-M-14 P167S apoenzyme | x-ray diffraction | A | — | 2 (best 0.42) |
| 5TWD | Ctx-M-14 P167S apoenzyme | x-ray diffraction | A | — | — |
| 5TWE | CTX-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime | x-ray diffraction | A | CAZ | — |
| 5TWE | Ctx-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime | x-ray diffraction | A | CAZ | — |
| 5VTH | CTX-M-14 P167S:E166A mutant | x-ray diffraction | A | — | 2 (best 0.38) |
| 5VTH | Ctx-M-14 P167S:E166A mutant | x-ray diffraction | A | — | — |
| 6CYK | CTX-M-14 N106S mutant | x-ray diffraction | A, B | — | 3 (best 0.73) |
| 6CYK | Ctx-M-14 N106S mutant | x-ray diffraction | A, B | — | — |
| 6CYN | CTX-M-14 N106S/D240G mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.80) |
| 6CYN | Ctx-M-14 N106S/D240G mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6CYQ | Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime | x-ray diffraction | A, B, C, D, E, F, G, H | CE4 | 20 (best 0.77) |
| 6CYQ | Crystal structure of ctx-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime | x-ray diffraction | A, B, C, D, E, F, G, H | CE4 | — |
| 6CYU | Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime | x-ray diffraction | A | CE4 | 2 (best 0.43) |
| 6CYU | Crystal structure of ctx-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime | x-ray diffraction | A | CE4 | — |
| 6D7H | CTX-M-14 Apoenzyme | x-ray diffraction | A | PO4, K | 1 (best 0.25) |
| 6D7H | Ctx-M-14 apoenzyme | x-ray diffraction | A | PO4, K | — |
| 6D7I | CTX-M-14 Apoenzyme D233N Point Mutant | x-ray diffraction | A | — | 1 (best 0.34) |
| 6D7I | Ctx-M-14 apoenzyme D233N point mutant | x-ray diffraction | A | — | — |
| 6V5E | Crystal structure of CTX-M-14 P167S/D240G beta-lactamase | x-ray diffraction | A | — | — |
| 6V5E | Crystal structure of ctx-M-14 P167S/D240G beta-lactamase | x-ray diffraction | A | — | — |
| 6V6G | Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase | x-ray diffraction | A | NA | 1 (best 0.33) |
| 6V6G | Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase | x-ray diffraction | A | NA | — |
| 6V6P | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase | x-ray diffraction | A | SO4 | 1 (best 0.32) |
| 6V6P | Crystal structure of ctx-M-14 E166A/D240G beta-lactamase | x-ray diffraction | A | SO4 | — |
| 6V7T | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase in complex with ceftazidime | x-ray diffraction | A, B | CAZ | 2 (best 0.78) |
| 6V7T | Crystal structure of ctx-M-14 E166A/D240G beta-lactamase in complex with ceftazidime | x-ray diffraction | A, B | CAZ | — |
| 6V83 | Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1 | x-ray diffraction | A | CAZ | 1 (best 0.33) |
| 6V83 | Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1 | x-ray diffraction | A | CAZ | — |
| 6V8V | Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-2 | x-ray diffraction | A | CAZ | 2 (best 0.64) |
| 6V8V | Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-2 | x-ray diffraction | A | CAZ | — |
| 7S0V | The role of an Asp-Asp pair in the structure, function and inhibition of CTX-M Class A… | x-ray diffraction | A | J1X | 1 (best 0.37) |
| 7S0V | The role of an asp-asp pair in the structure, function and inhibition of ctx-M class a… | x-ray diffraction | A | J1X | — |
| 8ELA | CTX-M-14 beta-lactamase mutant - N132A w MES | x-ray diffraction | A, B | SO4, ZN, CL | 2 (best 0.59) |
| 8ELB | CTX-M-14 beta-lactamase mutant- N132A | x-ray diffraction | A, B | — | 1 (best 0.60) |
Ligands
- CAZ · Acylated ceftazidime · in 10 records
- CE4 · (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2H-1,3-thiazine-4-carboxylic acid · in 4 records
- SO4 · Sulfate ion · in 3 records
- J1X · 3-(1H-pyrazol-1-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide · in 2 records
- K · Potassium ion · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- CL · Chloride ion · in 1 record
- ZN · Zinc ion · in 1 record
Elsewhere
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