MolNFT v1 · #166851 · protein
Crystal structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
6V2R · Chromobox protein homolog 7: “Crystal structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866”. X-ray diffraction, 2 ligands (5R0, UNX). MolNFT v1 #166851 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6V2R
- Type
- protein
- Length
- 59 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromobox protein homolog 7; UNC3866
- UniProt
- O95931
- Ligands
- 5R0, UNX
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromobox protein homolog 7 | protein | 54 | 31% helix, 46% strand | O95931 |
| B | UNC3866 | protein | 5 | 0% helix, 40% strand | — |
Ligands and binding sites
- 5R0 · 4-~{tert}-butylbenzoic acid · ligand · chains A, B
- UNX · Unknown atom or ion · ion · 17 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 551 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified, 1 covalent (nonstandard, covalent ligand).
Compared structures
- 6V2R · Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866 · the same entry in another collection · chain A against A, TM-score 1.00
- O95931 · AlphaFold monomer V2.0 prediction for chromobox protein homolog 7 (O95931) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95931
- Elsewhere: RCSB PDB 6V2R · PDBe 6V2R · UniProt O95931
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