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Crystal structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
Analyse Crystal structure of chromodomain of CBX7 mutant V13A in complex with inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V2R
- Type
- protein
- Length
- 59 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromobox protein homolog 7; UNC3866
- UniProt
- O95931
- Ligands
- 5R0, UNX
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromobox protein homolog 7 | protein | 54 | 31% helix, 46% strand | O95931 |
| B | UNC3866 | protein | 5 | 0% helix, 40% strand | — |
Ligands and binding sites
- 5R0 · 4-~{tert}-butylbenzoic acid · ligand · chains A, B
- UNX · Unknown atom or ion · ion · 17 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 551 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified, 1 covalent (nonstandard, covalent ligand).
Compared structures
- 6V2R · Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866 · the same entry in another collection · chain A against A, TM-score 1.00
- O95931 · AlphaFold monomer V2.0 prediction for chromobox protein homolog 7 (O95931) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95931
- Elsewhere: RCSB PDB 6V2R · PDBe 6V2R · UniProt O95931
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