MolNFT v1 · #166645 · protein

Gltph in complex with L-aspartate and sodium ions in intermediate outward-facing state

6UWL · Glutamate transporter homolog: “Gltph in complex with L-aspartate and sodium ions in intermediate outward-facing state”. Electron microscopy, 2 ligands (ASP, 6OU), 8 pockets (best druggability 0.53). MolNFT v1 #166645 on GenesisL1…

PDB: 6UWL
Type: protein
Length: 401 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate transporter homolog
Ligands: ASP, 6OU
Pockets: 8 · best druggability 0.53

Structure

electron microscopy · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate transporter homolog	protein	401	75% helix, 0% strand	—

Ligands and binding sites

ASP · Aspartic acid · ligand · chains A
6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	283	0.53	0.74	37	empty
2	54	0.45	0.84	14	empty
3	128	0.43	0.76	20	empty
4	58	0.37	0.79	14	empty
5	77	0.34	0.76	19	empty

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, formylation).

Compared structures

6UWL · GltPh in complex with L-aspartate and sodium ions in intermediate outward-facing state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6UWL · PDBe 6UWL

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