Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, lot a

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 48% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
• BMA · beta-D-mannopyranose · sugar · chains A
• GAL · beta-D-galactopyranose · sugar · chains A
• FUC · alpha-L-fucopyranose · sugar · chains A
• ZN · Zinc ion · metal · 3 copies · chains A
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 6UGW · Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0DOX5
• Elsewhere: RCSB PDB 6UGW · PDBe 6UGW · UniProt P0DOX5