MolNFT v1 · #165554 · protein
Crystal structure of candida albicans calcineurin a, calcineurin B, FKBP12 and FK506 (tacrolimus)
6TZ6: “Crystal structure of candida albicans calcineurin a, calcineurin B, FKBP12 and FK506 (tacrolimus)”. X-ray diffraction, 5 ligands (FK5, CA, ZN). MolNFT v1 #165554 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TZ6
- Type
- protein
- Length
- 1,230 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- C4YFI3, C4YS24, P28870
- Ligands
- FK5, CA, ZN, FE, PO4
Structure
x-ray diffraction · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 361 | — | C4YFI3 |
| B | — | protein | 141 | — | C4YS24 |
| C | — | protein | 116 | — | P28870 |
| D | — | protein | 352 | — | C4YFI3 |
| E | — | protein | 146 | — | C4YS24 |
| F | — | protein | 114 | — | P28870 |
Ligands and binding sites
- FK5 · 8-deethyl-8-[but-3-enyl]-ascomycin · ligand · 2 copies · chains A, B, C, D, E, F
- CA · Calcium ion · metal · 7 copies · chains B, E
- ZN · Zinc ion · metal · 2 copies · chains A, D
- FE · Fe (III) ion · metal · 2 copies · chains A, D
- PO4 · Phosphate ion · ion · 3 copies · chains A, D
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TZ6 · Crystal Structure of Candida Albicans Calcineurin A, Calcineurin B, FKBP12 and FK506… · the same entry in another collection · chain F against F, TM-score 1.00
- P28870 · AlphaFold monomer V2.0 prediction for FK506-binding protein 1 (P28870) · a predicted model of the same protein · chain F against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4YFI3
- Every structure of UniProt C4YS24
- Every structure of UniProt P28870
- Elsewhere: RCSB PDB 6TZ6 · PDBe 6TZ6 · UniProt C4YFI3 · UniProt C4YS24 · UniProt P28870
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.