UniProt P28870
FK506-binding protein 1 (P28870)
FK506-binding protein 1 (UniProt P28870), EC 5.2.1.8: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28870
- Protein
- FK506-binding protein 1
- EC
- 5.2.1.8
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
11 records of P28870 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HTG | Structure of apo P1 form of Candida albicans FKBP12 | x-ray diffraction | A, B | — | — |
| 5HTG | Structure of apo P1 form of candida albicans FKBP12 | x-ray diffraction | A, B | — | — |
| 5HW6 | Candida albicans FKBP12 apo protein in C2 space group | x-ray diffraction | A, B | — | — |
| 5HW6 | Candida albicans FKBP12 apo protein in C2 space group | x-ray diffraction | A, B | — | — |
| 5HW7 | Candida albicans FKBP12 apo protein in P21212 space group | x-ray diffraction | A, B | — | — |
| 5HW7 | Candida albicans FKBP12 apo protein in P21212 space group | x-ray diffraction | A, B | — | — |
| 5HW8 | Candida albicans FKBP12 P104G protein bound with FK506 in C2 space group | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5I98 | Structure of apo FKBP12(P104G) from C. albicans | x-ray diffraction | A, B | — | — |
| 6TZ6 | Crystal Structure of Candida Albicans Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus) | x-ray diffraction | C, F | FK5 | 7 (best 0.80) |
| 6TZ6 | Crystal structure of candida albicans calcineurin a, calcineurin B, FKBP12 and FK506 (tacrolimus) | x-ray diffraction | C, F | FK5 | — |
| P28870 | AlphaFold monomer V2.0 prediction for FK506-binding protein 1 (P28870) | predicted | A | — | — |
Ligands
- FK5 · 8-deethyl-8-[but-3-enyl]-ascomycin · in 2 records
Experiment against prediction
- 5I98 chain B against the predicted model P28870: TM-score 1.00, RMSD 0.21 Å
- 5I98 chain A against the predicted model P28870: TM-score 0.99, RMSD 0.40 Å
- 5HTG chain A against the predicted model P28870: TM-score 0.99, RMSD 0.44 Å
- 5HTG chain A against the predicted model P28870: TM-score 0.99, RMSD 0.44 Å
- 6TZ6 chain F against the predicted model P28870: TM-score 0.99, RMSD 0.44 Å
- 6TZ6 chain F against the predicted model P28870: TM-score 0.99, RMSD 0.44 Å
- 5HW7 chain B against the predicted model P28870: TM-score 0.98, RMSD 0.51 Å
- 5HW7 chain B against the predicted model P28870: TM-score 0.98, RMSD 0.51 Å
- 5HW8 chain C against the predicted model P28870: TM-score 0.98, RMSD 0.57 Å
- 6TZ6 chain C against the predicted model P28870: TM-score 0.98, RMSD 0.58 Å
Elsewhere
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