MolNFT v1 · #165497 · protein
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, datp, dtmpnpp and mg
6TXE: “Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, datp, dtmpnpp and mg”. X-ray diffraction, 6 ligands (1FZ, GTP, DTP). MolNFT v1 #165497 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TXE
- Type
- protein
- Length
- 7,654 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9Y3Z3
- Ligands
- 1FZ, GTP, DTP, MG, FE, SO4
Structure
x-ray diffraction · 13 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, H | — | protein | 480 | — | Q9Y3Z3 |
| B, E | — | protein | 479 | — | Q9Y3Z3 |
| C | — | protein | 480 | — | Q9Y3Z3 |
| D | — | protein | 481 | — | Q9Y3Z3 |
| F | — | protein | 478 | — | Q9Y3Z3 |
| G | — | protein | 479 | — | Q9Y3Z3 |
| I, N | — | protein | 477 | — | Q9Y3Z3 |
| J | — | protein | 478 | — | Q9Y3Z3 |
| K | — | protein | 478 | — | Q9Y3Z3 |
| L | — | protein | 478 | — | Q9Y3Z3 |
| M | — | protein | 475 | — | Q9Y3Z3 |
| O | — | protein | 481 | — | Q9Y3Z3 |
| P | — | protein | 474 | — | Q9Y3Z3 |
Ligands and binding sites
- 1FZ · 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine · ligand · 16 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
- GTP · Guanosine-5'-triphosphate · ligand · 16 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
- DTP · 2'-deoxyadenosine 5'-triphosphate · ligand · 16 copies · chains A, C, D, B, E, G, H, F, I, K, L, J, M, N, P, O
- MG · Magnesium ion · metal · 32 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
- FE · Fe (III) ion · metal · 16 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
- SO4 · Sulfate ion · ion · 11 copies · chains B, C, D, E, F, H, I, J, K, N, O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TXE · Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3Z3
- Elsewhere: RCSB PDB 6TXE · PDBe 6TXE · UniProt Q9Y3Z3
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