MolNFT v1 · #165005 · protein
Cryoem structure of the binary DOCK2-ELMO1 complex
6TGB · Dedicator of cytokinesis protein 2: “Cryoem structure of the binary DOCK2-ELMO1 complex”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #165005 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TGB
- Type
- protein
- Length
- 2,541 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dedicator of cytokinesis protein 2; Engulfment and cell motility protein 1
- UniProt
- Q92608, Q92556
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 51% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dedicator of cytokinesis protein 2 | protein | 1450 | 49% helix, 9% strand | Q92608 |
| B | Engulfment and cell motility protein 1 | protein | 680 | 54% helix, 6% strand | Q92556 |
| D | Dedicator of cytokinesis protein 2 | protein | 411 | 54% helix, 11% strand | Q92608 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 434 | 0.86 | 0.93 | 60 | empty |
| 2 | 969 | 0.84 | 0.85 | 126 | empty |
| 3 | 894 | 0.84 | 0.85 | 96 | empty |
| 4 | 1188 | 0.81 | 0.82 | 126 | empty |
| 5 | 530 | 0.79 | 0.86 | 71 | empty |
Interfaces
2 interfaces between chains.
- A–B · 2338 Ų buried · 36 hydrogen bonds · protein-protein
- A–D · 991 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6TGB · CryoEM structure of the binary DOCK2-ELMO1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q92608 · AlphaFold monomer V2.0 prediction for dedicator of cytokinesis protein 2 (Q92608) · a predicted model of the same protein · chain D against A, TM-score 0.93
- Q92556 · AlphaFold monomer V2.0 prediction for engulfment and cell motility protein 1 (Q92556) · a predicted model of the same protein · chain B against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92608
- Every structure of UniProt Q92556
- Elsewhere: RCSB PDB 6TGB · PDBe 6TGB · UniProt Q92608 · UniProt Q92556
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