MolNFT v1 · #164972 · protein

Carbamazepine binds FRIZZLED8

6TFB: “Carbamazepine binds FRIZZLED8”. X-ray diffraction, 1 ligand (N6W). MolNFT v1 #164972 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TFB
Type: protein
Length: 253 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q61091
Ligands: N6W

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	128	—	Q61091
B	—	protein	125	—	Q61091

Ligands and binding sites

N6W · benzo[b][1]benzazepine-11-carboxamide · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6TFB · Carbamazepine binds Frizzled8 · the same entry in another collection · chain A against A, TM-score 1.00
Q61091 · AlphaFold monomer V2.0 prediction for frizzled-8 (Q61091) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61091
Elsewhere: RCSB PDB 6TFB · PDBe 6TFB · UniProt Q61091

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