Research workbench
Carbamazepine binds FRIZZLED8
Analyse Carbamazepine binds FRIZZLED8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TFB
- Type
- protein
- Length
- 253 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Frizzled-8
- UniProt
- Q61091
- Ligands
- N6W
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Frizzled-8 | protein | 128 | 41% helix, 13% strand | Q61091 |
| B | Frizzled-8 | protein | 125 | 40% helix, 10% strand | Q61091 |
Ligands and binding sites
- N6W · benzo[b][1]benzazepine-11-carboxamide · ligand · 2 copies · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.43 | 0.78 | 20 | N6W |
| 2 | 85 | 0.34 | 0.74 | 22 | empty |
| 3 | 56 | 0.33 | 0.77 | 13 | N6W |
| 4 | 69 | 0.32 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 388 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61091
- Elsewhere: RCSB PDB 6TFB · PDBe 6TFB · UniProt Q61091
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